Corrigendum: The reverse evolution from multicellularity to unicellularity during carcinogenesis.

@article{Chen2015CorrigendumTR,
  title={Corrigendum: The reverse evolution from multicellularity to unicellularity during carcinogenesis.},
  author={Han Chen and Fangqin Lin and Ke Xing and Xionglei He},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          8812
        }
}
Theoretical reasoning suggests that human cancer may result from knocking down the genetic constraints evolved for maintenance of the metazoan multicellularity, which, however, requires a critical test. Using xenograft-based experimental evolution we characterized for the first time the full life history from initiation to metastasis of a tumor at the genomic and transcriptomic levels, and observed metastasis-driving positive selection for generally loss-of-function mutations on a set of… 
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