Corrigendum: Paraoxonase-1 is a major determinant of clopidogrel efficacy

  title={Corrigendum: Paraoxonase-1 is a major determinant of clopidogrel efficacy},
  author={Heleen J Bouman and Edgar Sch{\"o}mig and Jochem W. Van Werkum and Janna Velder and Christian Marcus Hackeng and Christoph Hirschh{\"a}user and Christopher M. Waldmann and Hans-G{\"u}nther Schmalz and Jurri{\"e}n M. ten Berg and Dirk Taubert},
  journal={Nature Medicine},
Clinical efficacy of the antiplatelet drug clopidogrel is hampered by its variable biotransformation into the active metabolite. The variability in the clinical response to clopidogrel treatment has been attributed to genetic factors, but the specific genes and mechanisms underlying clopidogrel bioactivation remain unclear. Using in vitro metabolomic profiling techniques, we identified paraoxonase-1 (PON1) as the crucial enzyme for clopidogrel bioactivation, with its common Q192R polymorphism… CONTINUE READING
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