Corrigendum: Germline stem cells and follicular renewal in the postnatal mammalian ovary

  title={Corrigendum: Germline stem cells and follicular renewal in the postnatal mammalian ovary},
  author={Joshua Johnson and Jacqueline Canning and Tomoko Kaneko and James K Pru and Jonathan L. Tilly},
This corrects the article DOI: nature02316 
Correction: Corrigendum: Germline stem cells and follicular renewal in the postnatal mammalian ovary
It is estimated that germline stem cells generate approximately 77 new primordial oocytes per day in ovaries of postnatal female mice.
A detour in the quest for oogonial stem cells: methods matter
Several independent groups question the reliability of an antibody-based method that is used to isolate oogonial stem cells from the ovaries of adult humans, nonhuman primates and mice.
Signaling pathways in the development of female germ cells
A large number of women are born with a fixed number of primordial follicles in the ovaries, which are the first small follicles to appear in the mammalian ovary.
Bone cells linked to creation of fresh eggs in mammals
Hackles rise over claims on ovulation.
Extragonadal primordial germ cells or placental progenitor cells?
  • K. Downs
  • Biology
    Reproductive biomedicine online
  • 2018
Location and characterization of female germline stem cells (FGSCs) in juvenile porcine ovary
Existence of germline stem cells (GSCs) in juvenile mammalian female ovaries has been drastically debated recently since reports that adult mouse ovaries still have mitotically active germ cells have
GSK3 inhibitor‐BIO regulates proliferation of female germline stem cells from the postnatal mouse ovary
It is widely believed that in most female mammalian neonates, all germ cells enter meiosis to form the primary oocyte at the end of foetal development, and as a result, the postnatal mammalian ovary
Stem cells in aged mammalian ovaries
The ovary undergoes several changes after the menopause. The main characteristics of the postmenopausal ovary are a loss of follicles and several changes as a consequence of apoptotic processes.


Commuting the death sentence: how oocytes strive to survive
  • J. Tilly
  • Biology
    Nature Reviews Molecular Cell Biology
  • 2001
New insights into the mechanisms that underlie germ-cell apoptosis have been provided by the study of oocyte death in lower organisms and in genetically manipulated mice that lack apoptosis-regulatory proteins.
Spermatogenesis following male germ-cell transplantation.
It is reported here that stem cells isolated from testes of donor male mice will repopulate sterile testes when injected into seminiferous tubules and may prove useful as a tool for biomedical science and biotechnology.
The stem-cell niche theory: lessons from flies
Findings in the Drosophila gonad studies are illuminating the understanding of the self-renewing mechanisms of tissue stem cells in general and the structure of the niche and the signalling pathways that it produces to regulate theSelf-Renewal of stem cells.
The tao of stem cells in the germline.
  • H. Lin
  • Biology
    Annual review of genetics
  • 1997
The establishment and self-renewing division of GSCs are controlled by extracellular signals such as hormones from the hypothalamic-pituitary axis and local interactions between G SCs and their neighboring cells.
Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency
It is shown that young adult female Bax–/– mice possess threefold more primordial follicles in their ovarian reserve than their wild–type sisters, and this surfeit of follicles is maintained in advanced chronological age, such that 20–22–month–old female BAX–/- mice possess hundreds of follicle at all developmental stages and exhibit ovarian steroid–driven uterine hypertrophy.
Female Germ Cell Aneuploidy and Embryo Death in Mice Lacking the Meiosis-Specific Protein SCP3
It is found that SCP3 is required for chiasmata formation and for the structural integrity of meiotic chromosomes, suggesting that altered chromosomal structure triggers nondisjunction and is thus linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes.
Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse.
The data indicate that the combined actions of SCF, LIF, and IGF-I are required for maximal inhibition of apoptosis in germ cells of fetal mouse ovaries, and that the PI3K signaling pathway is an essential component of cytokine-mediated female germ cell survival.
Stem cells find their niche
Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut, and promise to advance efforts to use stem cells therapeutically.
Regulation of meiotic recombination and prophase I progression in mammals
  • P. CohenJ. Pollard
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2001
This review will focus on the recent studies involving mouse mutants for meiotic recombination, and will highlight important differences between traditional model systems for meiosis and those involving more complex cellular, physiological and genetic criteria.
Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles.
It is shown that mouse cysts undergo programmed breakdown between 20.5-22.5 dpc, during which approximately 33% of the oocytes survive to form primordial follicles, which suggests that perinatal germ cell loss is a developmentally regulated process that is distinct from the follicular atresia that occurs during adult life.