Corrigenda: Counterion displacement in the molecular evolution of the rhodopsin family

@article{Terakita2004CorrigendaCD,
  title={Corrigenda: Counterion displacement in the molecular evolution of the rhodopsin family},
  author={Akihisa Terakita and Mitsumasa Koyanagi and Hisao Tsukamoto and Takahiro Yamashita and Takashi Miyata and Yoshinori Shichida},
  journal={Nature Structural &Molecular Biology},
  year={2004},
  volume={11},
  pages={284-289}
}
The counterion, a negatively charged amino acid residue that stabilizes a positive charge on the retinylidene chromophore, is essential for rhodopsin to receive visible light. The counterion in vertebrate rhodopsins, Glu113 in the third transmembrane helix, has an additional role as an intramolecular switch to activate G protein efficiently. Here we show on the basis of mutational analyses that Glu181 in the second extracellular loop acts as the counterion in invertebrate rhodopsins. Like… CONTINUE READING
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