Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system.

@article{AidiKnani2015CorrespondencesBT,
  title={Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system.},
  author={Sabrine Aidi-Knani and Laurent Pezard and Bedel Mpari and Jeannette Ben Hamida and Jean-Marc Sabatier and Christiane Mourre and Imed Regaya},
  journal={European journal of pharmacology},
  year={2015},
  volume={752},
  pages={
          106-11
        }
}
Small-conductance calcium-activated potassium channels (SK1-SK3 channels) are responsible for long-lasting hyperpolarization following action potential and contribute to the neuronal firing and integration signal. Two peptide toxins: apamin and Leiurotoxin 1, block this SK channels with high affinities. We generated a modified Leiurotoxin 1 (Lei-Dab7) that inhibits SK2 channels with a high selectivity. Competitive binding of radio-iodinated apamin to different rat brain structures, in the… CONTINUE READING
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