Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research.

@article{Walton2016CorrespondenceOD,
  title={Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research.},
  author={Esther Walton and Johanna Hass and Jingyu Liu and Joshua L. Roffman and Fabio Bernardoni and Veit R{\"o}\ssner and Matthias Kirsch and Gabriele Schackert and Vince D. Calhoun and Stefan Ehrlich},
  journal={Schizophrenia bulletin},
  year={2016},
  volume={42 2},
  pages={406-14}
}
Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry concerns the extent to which epigenetic signatures measured in more accessible tissues such as blood can serve as a surrogate marker for the brain. Here, we aimed (1) to investigate the blood-brain correspondence of DNA methylation using a within-subject design and (2) to identify changes in DNA methylation of brain-related biological pathways in schizophrenia.We obtained paired blood and temporal lobe… CONTINUE READING
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