Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

@article{Kurtzhals2000CorrelationsOR,
  title={Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.},
  author={Peter Kurtzhals and Lauge Sch{\"a}ffer and Anders S\orensen and Claus Kristensen and Ib Jonassen and Christine J. Schmid and Thomas Tr{\"u}b},
  journal={Diabetes},
  year={2000},
  volume={49 6},
  pages={999-1005}
}
In recent years, analogs of human insulin have been engineered with the aim of improving therapy for people with diabetes. To ensure that the safety profile of the human hormone is not compromised by the molecular modifications, the toxico-pharmacological properties of insulin analogs should be carefully monitored. In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys… CONTINUE READING
Highly Influential
This paper has highly influenced 38 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
259 Extracted Citations
52 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 259 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 52 references

Pharmacokinetic and pharmacodynamic properties of insulin analog NN304 in comparison to NPH insulin in humans (Abstract)

  • GA Brunner, G Sendlhofer, +6 authors TR Pieber
  • Diabetes 48 (Suppl. 1):A102,
  • 1999

Vølund A: Insulin analogs with improved pharmacokinetic profiles

  • J Brange
  • Adv Drug Deliv Rev 35:307–335,
  • 1999

Similar Papers

Loading similar papers…