Correlations in the T Cell Response to Altered Peptide Ligands

  title={Correlations in the T Cell Response to Altered Peptide Ligands},
  author={Jeong-Man Park and Michael W. Deem},
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases. We present a random energy theory for the correlations in the naive and memory T cell immune responses. The non-linear susceptibility of the random energy model to structural changes captures the correlations in the immune response to mutated antigens. We show how the sequence-level… CONTINUE READING


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