Correlations between water maze performance and cortical somatostatin mRNA and high-affinity binding sites during ageing in rats.

@article{Dournaud1996CorrelationsBW,
  title={Correlations between water maze performance and cortical somatostatin mRNA and high-affinity binding sites during ageing in rats.},
  author={Pascal Dournaud and F R Jazat-Poindessous and Abdelhamid Slama and Yvon A. Lamour and Jacques Epelbaum},
  journal={The European journal of neuroscience},
  year={1996},
  volume={8 3},
  pages={476-85}
}
Somatostatin levels and high-affinity (somatostatin-1) binding sites are decreased in post-mortem cortical samples of Alzheimer's disease patients but the relationships between such modifications and the cognitive deficits remain to be established. We investigated these relationships in the ageing rat. Three age groups (3-4, 14-15 and 26-27 months) were tested in a modified version of the Morris water maze. Somatostatin mRNA levels were quantified by in situ hybridization and somatostatin… CONTINUE READING
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