Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)

@article{Darusman2013CorrelationsBS,
  title={Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)},
  author={H. Darusman and D. Sajuthi and O. Kalliokoski and K. Jacobsen and J. Call and S. Schapiro and A. Gjedde and K. Abelson and J. Hau},
  journal={Journal of Medical Primatology},
  year={2013},
  volume={42}
}
In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1–42 (Aβ42) in serum, and total tau (t‐tau) and phosphorylated tau (p‐tau) levels in cerebrospinal fluid. 
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References

SHOWING 1-10 OF 47 REFERENCES
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans
TLDR
Amyloid‐β42 (Aβ42) appears central to Alzheimer's disease pathogenesis and is a major component of amyloid plaques, and its decrease may reflect plaques acting as an Aβ42 “sink,” hindering transport of soluble A β42 between brain and CSF. Expand
Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition
TLDR
The results suggest that the cynomolgus monkey can be used to elucidate the age-dependent sequence of Abeta and tau pathologies. Expand
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
TLDR
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance. Expand
Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains.
TLDR
Results suggest that intensive investigation of age-related changes in the nerve ending and in axonal transport will contribute to a better understanding of the pathogenesis of neurodegenerative disorders such as AD. Expand
Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain
TLDR
A strong positive correlation between changes in brain ISF Aβ concentrations and neurological status is found, with A β concentrations increasing as neurological status improved and falling when neurological status declined. Expand
CSF biomarkers for mild cognitive impairment and early Alzheimer's disease
TLDR
Three cerebrospinal fluid biomarkers have high sensitivity to differentiate early and incipient AD from normal aging, depression, alcohol dementia and Parkinson's disease, but lower specificity against other dementias, such as frontotemporal and Lewy body dementia. Expand
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
TLDR
The rationales behind and the diagnostic performances of the core cerebrospinal fluid biomarkers for AD, namely total tau, phosphorylated tau and the 42 amino acid form of amyloid-β are presented. Expand
Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys
TLDR
The present study describes the histopathological features of SPs and CAA in old cynomolgus monkeys and finds that the polyclonal antiserum was more sensitive than the monoclonal antibody. Expand
Amyloid-ss Dynamics Correlate with Neurological Status in the Injured Human Brain
TLDR
There was a strong positive correlation between changes in brain ISF Aβ concentrations and neurological status, with A β concentrations increasing as neurological status improved and falling when neurological status declined, which fit well with the hypothesis that neuronal activity regulates extracellular Aβ concentration. Expand
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
TLDR
The sequence of early tau phosphorylation suggests that there are events prior to filament formation that are specific to particular phosphorylated tau epitopes, leading to conformational changes and cytopathological alterations. Expand
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