Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population.

@article{Yamada2000CorrelationsBP,
  title={Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population.},
  author={Yasukazu Yamada and Hiroto Yoshida and Sahoko Ichihara and Tsutomu Imaizumi and Kei Satoh and Mitsuhiro Yokota},
  journal={Atherosclerosis},
  year={2000},
  volume={150 1},
  pages={209-16}
}
Platelet-activating factor acetylhydrolase (PAF-AH), a plasma enzyme that hydrolyzes PAF and oxidized phospholipids, is thought to be involved in protecting cells against oxidative stress. A G(994) (M allele)-->T (m allele) mutation in the plasma PAF-AH gene, which results in a Val(279)-->Phe substitution in the mature protein, leads to a loss of catalytic activity. To elucidate the relationships among PAF-AH enzyme activity, genotype, age, and atherosclerosis, we assayed these parameters in a… CONTINUE READING