Correlations between cell surface protease activities and abnormalities of occludens junctions in rat bladder carcinoma in vitro.

Microenvironmental alterations, i.e., proteolytic enzymes, may play a causative role in abnormalities of zonulae occludentes. To test this hypothesis, we compared in vitro the ultrastructure of three carcinoma cell lines which were derived from N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced tumors of the rat urinary bladder. One of these lines had a… (More)