Correlations between MRS and DTI in cerebral small vessel disease.

  title={Correlations between MRS and DTI in cerebral small vessel disease.},
  author={Arani Nitkunan and Dominick J. O. McIntyre and Thomas R. Barrick and Michael D O'Sullivan and Yuji Shen and Chris A Clark and Franklyn A. Howe and Hugh S. Markus},
  journal={NMR in biomedicine},
  volume={19 5},
Cerebral small vessel disease results in lacunar infarcts and cognitive impairment. Diffusion tensor imaging (DTI) demonstrates a reduction in fractional anisotropy and increase in mean diffusivity, which correlates more strongly with cognition than conventional MRI. The underlying pathological basis for these DTI changes is not known. In this study magnetic resonance spectroscopy was used to determine the biochemical basis of these DTI alterations. Twenty-five patients with lacunar stroke and… CONTINUE READING