Correlations between Arterial Hypertension Induced by Angiotensin Ii and Systemic Inflammation in Rat.

Abstract

UNLABELLED Angiotensin II has articularly shown to play a key role in the regulation of inflammatory processes in hypertension. AIM The present study aims to correlate the angiotensin II-induced hypertension 4th systemic inflammation. MATERIAL AND METHODS We conducted an experimental study on Wistar male rats who received Ang II via subcutaneous miniosmotic pumps for 2 weeks. Rats were exposed to a 12h light /12h dark cycle. Sham rats were used as control. Systolic load pressure measurements and a flow cytometric analysis of lymphocyte surface markers were performed. After 14 days, the animals were euthanized under anesthesia with ylazine/ketaniine. RESULTS Systolic BP progressively and significantly increased in rats 4th Ang II chronic infusion. We observed a statistical significant difference (p = 0.00001), in terms of T lymphocytes percentage between control rats plasma and Ang H treated rats lasma, in 14 days. CONCLUSIONS Angiotensin II is an important mediator of hypertension and directly promotes inflammation by noticeably increasing the quantity of T cells in kidney tissue.

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@article{Mrnduc2016CorrelationsBA, title={Correlations between Arterial Hypertension Induced by Angiotensin Ii and Systemic Inflammation in Rat.}, author={Minela Aida Mărănducă and Elena Cojocaru and Eugen Carasevici}, journal={Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i}, year={2016}, volume={120 1}, pages={77-82} }