Correlations Between the Morphology of Sonic Hedgehog Expression Domains and Embryonic Craniofacial Shape

@article{Xu2015CorrelationsBT,
  title={Correlations Between the Morphology of Sonic Hedgehog Expression Domains and Embryonic Craniofacial Shape},
  author={Qiuping Xu and Heather A. Jamniczky and Diane Hu and Rebecca M Green and Ralph S Marcucio and Benedikt Hallgr{\'i}msson and Washington Mio},
  journal={Evolutionary Biology},
  year={2015},
  volume={42},
  pages={379-386}
}
Quantitative analysis of gene expression domains and investigation of relationships between gene expression and developmental and phenotypic outcomes are central to advancing our understanding of the genotype–phenotype map. Gene expression domains typically have smooth but irregular shapes lacking homologous landmarks, making it difficult to analyze shape variation with the tools of landmark-based geometric morphometrics. In addition, 3D image acquisition and processing introduce many artifacts… CONTINUE READING

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