Correlation of vaccine-elicited systemic and mucosal nonneutralizing antibody activities with reduced acute viremia following intrarectal simian immunodeficiency virus SIVmac251 challenge of rhesus macaques.

@article{Hidajat2009CorrelationOV,
  title={Correlation of vaccine-elicited systemic and mucosal nonneutralizing antibody activities with reduced acute viremia following intrarectal simian immunodeficiency virus SIVmac251 challenge of rhesus macaques.},
  author={Rachmat Hidajat and Peng Xiao and Qifeng Zhou and David J Venzon and L. Ebonita Summers and Vaniambadi S. Kalyanaraman and David C. Montefiori and Marjorie Robert-Guroff},
  journal={Journal of virology},
  year={2009},
  volume={83 2},
  pages={791-801}
}
Cell-mediated immunity and neutralizing antibodies contribute to control of human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but the role of nonneutralizing antibodies is not defined. Previously, we reported that sequential oral/oral or intranasal/oral (I/O) priming with replication-competent adenovirus type 5 host range mutant (Ad5hr)-SIV recombinants, followed by intramuscular envelope protein boosting, elicited systemic and mucosal cellular immunity and… CONTINUE READING
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