Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat.

@article{Scollon2011CorrelationOT,
  title={Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat.},
  author={Edward J Scollon and J M Starr and Kevin M. Crofton and Marcelo Javier Wolansky and Michael J. Devito and Michael F Hughes},
  journal={Toxicology},
  year={2011},
  volume={290 1},
  pages={1-6}
}
The potential for human exposure to pyrethroid pesticides has prompted pharmacodynamic and pharmacokinetic research to better characterize risk. This work tested the hypothesis that blood and brain concentrations of the pyrethroid bifenthrin are predictive of neurotoxic effects. Adult male Long Evans rats received a single oral dose of bifenthrin dissolved in corn oil. Using figure-eight mazes, motor activity was measured for 1h at 4- and 7-h following exposure to bifenthrin (0-16mg/kg or 0-9mg… CONTINUE READING