Correlation of the Km(1) immunoglobulin allotype with anti-polysaccharide antibodies in Caucasian adults.

@article{Ambrosino1986CorrelationOT,
  title={Correlation of the Km(1) immunoglobulin allotype with anti-polysaccharide antibodies in Caucasian adults.},
  author={D. Ambrosino and V. Barrus and G. G. deLange and G. Siber},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={78 2},
  pages={
          361-5
        }
}
  • D. Ambrosino, V. Barrus, +1 author G. Siber
  • Published 1986
  • Biology, Medicine
  • The Journal of clinical investigation
  • Km allotype antigens are serologic markers expressed on kappa light chains of human immunoglobulins. To determine whether th Km phenotype of an individual is related to his ability to make antibodies to polysaccharide antigens, we correlated the Km allotypes of 129 healthy caucasian adults with the concentrations of specific antibodies to three bacterial polysaccharide antigens after immunization. The 14 individuals expressing the Km(1) allotype had lower concentrations of IgG, IgM, and IgA… CONTINUE READING
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