Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis.

@article{Bradley1992CorrelationOS,
  title={Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis.},
  author={John Douglas Bradley and Anita C. Rudy and Barry P. Katz and S M Ryan and L. A. Kalasinski and Dr D. Craig Brater and Stephen D. Hall and Kenneth D. Brandt},
  journal={The Journal of rheumatology},
  year={1992},
  volume={19 1},
  pages={130-4}
}
Stereoselective pharmacokinetic measurements of the active enantiomer, S-ibuprofen, were correlated with clinical response in 45 participants in a randomized double blinded 4 week comparison of ibuprofen, 1200 or 2400 mg/day, for treatment of hip or knee osteoarthritis. Ibuprofen dose correlated with S-ibuprofen area under the serum concentration curve (AUC… CONTINUE READING