Corpus ID: 37219734

Correlation of retinoic acid-enhanced sialyltransferase activity and glycosylation of specific cell surface sialoglycoproteins with growth inhibition in a murine melanoma cell system.

@article{Lotan1984CorrelationOR,
  title={Correlation of retinoic acid-enhanced sialyltransferase activity and glycosylation of specific cell surface sialoglycoproteins with growth inhibition in a murine melanoma cell system.},
  author={Reuben Lotan and Dafna Lotan and L Meromsky},
  journal={Cancer research},
  year={1984},
  volume={44 12 Pt 1},
  pages={
          5805-12
        }
}
Retinoic acid inhibits the proliferation of the murine melanoma clone S91-C-2 cells, enhances the glycosylation of specific cell surface sialoglycoproteins, and stimulates sialytransferase activity. Mutant clones, selected from the S91-C-2 cells for resistance to the growth-inhibitory effect of retinoic acid, were used to explore whether cell surface modulation by retinoic acid is related to growth inhibition. Glycoprotein synthesis was assessed by analysis of [3H]glucosamine incorporation into… Expand
Enhancement of sialyltransferase in two melanoma cell lines that are growth-inhibited by retinoic acid results in increased sialylation of different cell-surface glycoproteins.
TLDR
The findings suggest that although RA can increase the activity of sialyltransferase in different melanoma cells, this increased activity may, in turn, result in an increased sIALylation of distinct cell-surface glycoproteins. Expand
Enhancement of glycosylation of cellular glycoconjugates in the squamous carcinoma cell line MDA886Ln by β-all-trans retinoic acid
TLDR
It is demonstrated that β-all-trans retinoic acid enhanced the incorporation of specific monosaccharides into a variety of glycoconjugates and in particular into HMW mucin-like glycconjugates. Expand
Growth inhibition of murine melanoma cells by antibodies to a cell surface glycoprotein implicated in retinoic acid action.
TLDR
The suggestion that cell surface gp160 might be involved in growth regulation in the S91-C2 cells is supported using specific antibodies to this glycoprotein. Expand
Retinoids enhance lectin binding to gp130, a glycoprotein of NIH-3T3 cells: correlation with cell growth and adhesion.
TLDR
RA-induced cell adhesiveness and growth inhibition are accompanied by an increase in the PHA-L, PHA -E, SBA, RCA, and sWGA binding to gp130, which suggests that it is a cell surface glycoprotein. Expand
Effect of Retinole Acid and Phorbol-12-myristate-13-acetate on Glycosyltransferase Activities in Normal and Transformed Cells 1
Retinole acid was found to increase the activity of cytidine monophosphosialic acid:lactosylceramide sialyltransferase activity in a nontransformed clonal hamster cell line, NIL 8, and a virallyExpand
Induction of reversible changes in cell‐surface glycoconjugates and lung colonization potential by 13‐cis retinoic acid
TLDR
The finding that RA treatment did not perturb the cell cycle of KLN205 cells provides further proof that the decreased metastatic behavior is not attributable to any inhibition in the rate of growth or to alterations in thecell cycle. Expand
Modulation by retinoids of mRNA levels for nuclear retinoic acid receptors in murine melanoma cells.
TLDR
It is demonstrated that RA can, directly and rapidly, induce the expression of mRNA for a high affinity nuclear receptor in some murine melanoma cells and that this induction is not sufficient to inhibit growth. Expand
Effect of retinoids on the proliferation, morphology and expression of glial fibrillary acidic protein of an anaplastic astrocytoma cell line
TLDR
An enzyme‐linked immunosorbent assay showed that all‐trans or 13‐cis retinoic acid caused a dose‐dependent increase in the quantity of glial fibrillary acidic protein in the astrocytoma cells, and prevented the EDTA‐induced cell detachment seen in control cultures. Expand
Up-regulation of embryonic NCAM in an EC cell line by retinoic acid.
The impact of retinoic acid (RA) on the expression of the neural cell adhesion molecules (NCAMs) and their developmentally regulated polysialic acid (PSA) moiety was studied in embryonal carcinomaExpand
Carbohydrate structure in tumor immunity
TLDR
Mechanisms by which the immune system can recognize these carbohydrate structures are considered, and immune recognition of tumor-associated carbohydrate structural alterations is explored. Expand
...
1
2
3
...