Corpus ID: 37219734

Correlation of retinoic acid-enhanced sialyltransferase activity and glycosylation of specific cell surface sialoglycoproteins with growth inhibition in a murine melanoma cell system.

@article{Lotan1984CorrelationOR,
  title={Correlation of retinoic acid-enhanced sialyltransferase activity and glycosylation of specific cell surface sialoglycoproteins with growth inhibition in a murine melanoma cell system.},
  author={Reuben Lotan and Dafna Lotan and L Meromsky},
  journal={Cancer research},
  year={1984},
  volume={44 12 Pt 1},
  pages={
          5805-12
        }
}
  • Reuben Lotan, Dafna Lotan, L Meromsky
  • Published 1984
  • Biology, Medicine
  • Cancer research
  • Retinoic acid inhibits the proliferation of the murine melanoma clone S91-C-2 cells, enhances the glycosylation of specific cell surface sialoglycoproteins, and stimulates sialytransferase activity. Mutant clones, selected from the S91-C-2 cells for resistance to the growth-inhibitory effect of retinoic acid, were used to explore whether cell surface modulation by retinoic acid is related to growth inhibition. Glycoprotein synthesis was assessed by analysis of [3H]glucosamine incorporation into… CONTINUE READING