Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli.

@article{Piddock1990CorrelationOQ,
  title={Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli.},
  author={Laura J V Piddock and Richard N. Walters and J. M. Diver},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 12},
  pages={2331-6}
}
The effects of nalidixic acid and four fluoroquinolones on DNA, RNA, and protein synthesis in the presence and absence of 20 mg of chloramphenicol per liter were examined by comparing the killing kinetics, MIC, morphological response, and maximum concentration to induce recA in Escherichia coli. All agents demonstrated paradoxical killing kinetics, in that above an optimum concentration the rate of bactericidal action was slower. Filamentation of E. coli AB1157 was observed with all quinolones… CONTINUE READING

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Induction of the SOS response in Escherichia coli by 4-quinolone antimicrobial agents

  • L.J.V. Piddock, R. Wise
  • FEMS Microbiol
  • 1987
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