Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients.

@article{House2007CorrelationOP,
  title={Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients.},
  author={Michael House and Tim St Pierre and Kris V. Kowdley and Thomas J. Montine and James Connor and J. P. Beard and Jos{\'e} Berger and Narendra Siddaiah and Eric G. Shankland and Lee-way Jin},
  journal={Magnetic resonance in medicine},
  year={2007},
  volume={57 1},
  pages={172-80}
}
Iron accumulates in the Alzheimer's disease (AD) brain and is directly associated with beta-amyloid pathology. The proton transverse relaxation rate (R(2)) has a strong linear relationship with iron concentrations in healthy brain tissue; however, an independent test of this relationship has not been extended to AD brain tissue. In this study in vitro single spin-echo (SE) measurements were made on tissue samples from four human AD brains using a 4.7T MRI research scanner. R(2) values were… CONTINUE READING

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