Correlation of plasma monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1alpha (MIP-1alpha) levels with disease activity and clinical course of sarcoidosis.

@article{Hashimoto1998CorrelationOP,
  title={Correlation of plasma monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1alpha (MIP-1alpha) levels with disease activity and clinical course of sarcoidosis.},
  author={Shu Hashimoto and Takashi Nakayama and Y Gon and Nobuhiko Hata and Takahiro Koura and Shuichiro Maruoka and Kenji Matsumoto and Shinya Hayashi and Yasunobu Abe and Takashi Horie},
  journal={Clinical and experimental immunology},
  year={1998},
  volume={111 3},
  pages={604-10}
}
MCP-1 and MIP-1alpha exhibit chemotactic activity toward macrophages/monocytes and induce the production of inflammatory cytokines affecting granuloma formation. Up-regulated expression of MCP-1 and MIP-1alpha in the affected organ of sarcoidosis has been shown; however, the relationship between their plasma levels and the clinical course of this disease has not been determined. In the present study we measured plasma MCP-1 and MIP-1alpha levels in 26 patients with active sarcoidosis by ELISA… CONTINUE READING
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