Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma.

@article{Cifone1980CorrelationOP,
  title={Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma.},
  author={Maria A. Cifone and Isaiah Josh Fidler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 2},
  pages={1039-43}
}
The pattern of in vitro anchorage-independent growth of tumor cells from the murine UV-2237 fibrosarcoma correlated with their ability to produce experimental metastasis in vivo. When seeded into 0.3% Noble agar semisolid medium, cells of metastatic clones developed into larger tumor colonies at a faster rate than did cells of clones with low metastatic potential. Furthermore, when tumor cells were plated into 0.6% Noble agar, colony development by cells of low metastatic potential clones was… CONTINUE READING

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