Correlation of p53 protein expression with apoptotic incidence in colorectal neoplasia

  title={Correlation of p53 protein expression with apoptotic incidence in colorectal neoplasia},
  author={Michiyo Kobayashi and Hidenobu Watanabe and Yoichi Ajioka and Masayuki Yoshida and Jiro Hitomi and Hideki Asakura},
  journal={Virchows Archiv},
The wild-type p53 gene suppresses cell proliferation and induces apoptosis when it is transfected into human colon cancer cell lines. Therefore, mutation of the p53 gene, which correlates closely with p53 protein overexpression, would be predicted to activate cell proliferation and limit apoptosis. We tested this hypothesis by correlating p53 protein expression with cell proliferation and apoptosis in 70 neoplasms (29 adenomas and 41 carcinomas) using p53 and Ki-67 immunohistochemical staining… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.
Showing 1-10 of 33 references

cycle arrest and gene amplification potential accompany loss of wild - type p 53

  • S Maeo, Y Ajioka, H Watanabe, M Kobayashi
  • 1995

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

  • IO Bass, JWR Mulder, JA Offerhaus, B Vogelstein, SR Hamilton
  • J Pathol (Lond)
  • 1994
2 Excerpts

Prognostic significance of p 53 expression in relation to DNA ploidy in colorectal adenocarcino

  • H Tsuda, S Hirohashi
  • Virchows Arch [ A ]
  • 1994

Similar Papers

Loading similar papers…