Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer.

@article{Liu2015CorrelationOP,
  title={Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer.},
  author={Sandy Z Liu and Dan P Zandberg and Lisa M. Schumaker and John C. Papadimitriou and Kevin J. Cullen},
  journal={Oral oncology},
  year={2015},
  volume={51 9},
  pages={862-9}
}
OBJECTIVES Examine the effect of concordance between p16 overexpression and HR (high risk) HPV DNA status on overall survival in a large series of oropharyngeal squamous cell carcinoma (OPSCC) cases. MATERIALS AND METHODS A total of 185 patients with primary OPSCC had genomic DNA tested by PCR for the HPV16 E6 and E7 oncogenes. 184 of 185 patients had p16 IHC performed. Linear array HPV genotyping was performed in all 21 HPV16/p16 discordant cases (HPV16+/p16- or HPV16-/p16+) as well as in 43… CONTINUE READING