Correlation of mutagenic and dermal carcinogenic activities of mineral oils with polycyclic aromatic compound content.

@article{Roy1988CorrelationOM,
  title={Correlation of mutagenic and dermal carcinogenic activities of mineral oils with polycyclic aromatic compound content.},
  author={Tarak Roy and Stephen W. Johnson and Gary R. Blackburn and Carl R. Mackerer},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1988},
  volume={10 3},
  pages={466-76}
}
Mutagenicity, polynuclear aromatic compound content, and skin carcinogenicity were compared for a series of complex oil mixtures derived from the refining and processing of petroleum. Mutagenicity in a modified Ames Salmonella assay showed an excellent correlation with carcinogenicity, as determined in a mouse skin-painting bioassay, for oil samples with median boiling points (defined as the temperature at which 50%/volume of an oil sample is recovered as condensate during distillation--50… CONTINUE READING

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