Correlation of karyotype with clinical features in acute lymphoblastic leukemia.

  title={Correlation of karyotype with clinical features in acute lymphoblastic leukemia.},
  author={Yasuhiko Kaneko and Janet D. Rowley and Daina Variakojis and Robert R. Chilcote and Irene J. Check and Masaharu Sakurai},
  journal={Cancer research},
  volume={42 7},
We studied the clinical and karyotypic features of 50 patients with acute lymphoblastic leukemia, including 33 American and 17 Japanese patients, at two institutions. Clonal chromosome abnormalities were found in 39 of the 50 patients (78%) at diagnosis. Eleven patients had diploidy (N patients). Among the 39 aneuploid patients, 17 had pseudodiploidy (A1 patients), eight had hyperdiploidy with 47 to 49 chromosomes (A2 patients), nine had hyperdiploidy with 50 to 59 chromosomes (A3 patients… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 29 extracted citations

Tumor Aneuploidy

Springer Berlin Heidelberg • 1985
View 6 Excerpts
Highly Influenced

Genomic heterogeneity in acute leukemia.

Cytogenetic and genome research • 2013
View 8 Excerpts
Highly Influenced

AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.

Proceedings of the National Academy of Sciences of the United States of America • 2011

Similar Papers

Loading similar papers…