Correlation of intrahepatic pressure with collagen in the Disse space and hepatomegaly in humans and in the rat.

@article{Orrego1981CorrelationOI,
  title={Correlation of intrahepatic pressure with collagen in the Disse space and hepatomegaly in humans and in the rat.},
  author={H{\'e}ctor M. Orrego and Laurence M Blendis and I R Crossley and Alan Medline and Anita Macdonald and Stephen R Ritchie and Yedy Israel},
  journal={Gastroenterology},
  year={1981},
  volume={80 3},
  pages={546-56}
}
In 70 alcoholic patients the amount of collagen in the space of Disse was compared, using an electron microscopic graded score, to the height of the intrahepatic pressure. A highly significant correlation was found between the amount of collagen and intrahepatic pressure in the group as a whole (r = 0.84; p < 10(-6)), as well as in subgroups of 30 alcoholic patients with normal livers or steatosis (r = 0.83; p < 10(-6)), 9 patients with alcoholic hepatitis (r = 0.81; p < 0.01), and 31 with… CONTINUE READING