Correlation of increases in 1,25-dihydroxyvitamin D during vitamin D therapy with activation of CD4+ T lymphocytes in HIV-1-infected males.

@article{Bang2012CorrelationOI,
  title={Correlation of increases in 1,25-dihydroxyvitamin D during vitamin D therapy with activation of CD4+ T lymphocytes in HIV-1-infected males.},
  author={U C Bang and Lilian Kolte and Mette F Hitz and Susanne Dam Nielsen and Louise Lind Schierbeck and Ove Andersen and Steen Bendix Haugaard and Lars Mathiesen and Thomas Benfield and Jens-Erik B Jensen},
  journal={HIV clinical trials},
  year={2012},
  volume={13 3},
  pages={162-70}
}
BACKGROUND In HIV-1-infected individuals, levels of CD4+ T lymphocytes are depleted and regulatory T-lymphocytes (Tregs) are elevated. In vitro studies have demonstrated effects of vitamin D on the growth and differentiation of these cells. We speculated whether supplementation with vitamin D could have an effect on CD4+ T lymphocytes or Tregs in HIV-1-infected males. METHODS We conducted a placebo-controlled randomized study that ran for 16 weeks and included 61 HIV-1-infected males, of whom… CONTINUE READING