Correlation of immunoregulatory function with cell phenotype in cord blood lymphocytes.

@article{Kingsley1988CorrelationOI,
  title={Correlation of immunoregulatory function with cell phenotype in cord blood lymphocytes.},
  author={Gabrielle H. Kingsley and Costantino Pitzalis and A P Waugh and Gabriel S. Panayi},
  journal={Clinical and experimental immunology},
  year={1988},
  volume={73 1},
  pages={40-5}
}
The strong suppressor activity of cord T lymphocytes contrasts markedly with their mainly CD4 (helper) rather than CD8 (suppressor) phenotype. We studied the phenotype of cord CD3, CD4 and CD8 cells compared to adult cells using the monoclonal antibodies, 2H4, 4B4, and UCHL1. Almost all cord CD4 lymphocytes carried the suppressor-inducer marker 2H4, whereas 4B4+ UCHL1+ helper-inducer cells were virtually absent; CD8 cord cells were also of the 2H4+ 4B4- UCHL1- phenotype. In contrast in adult… CONTINUE READING