Correlation of immunomodulatory and therapeutic activities of interferon and interferon inducers in metastatic disease.

@article{Black1988CorrelationOI,
  title={Correlation of immunomodulatory and therapeutic activities of interferon and interferon inducers in metastatic disease.},
  author={P. Mc L. Black and Harold Phillips and Henry R. Tribble and Richard Pennington and Michael Schneider and James E Talmadge},
  journal={Journal of cellular biochemistry},
  year={1988},
  volume={36 4},
  pages={377-92}
}
The mechanism of therapeutic activity of recombinant murine interferon-gamma (rMu IFN-gamma) and the IFN inducer polyinosinic-polycytidylic acid solubilized with poly-L-lysine in carboxy methyl cellulose (pICLC) in treating metastatic disease was investigated by comparing effector cell augmentation with therapeutic activity in mice bearing experimental lung metastases (B16-BL6 melanoma). Effector cell functions in spleen, peripheral blood, and lung (the organ with tumor) were tested after 1 and… CONTINUE READING
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