Correlation of hypoxia inducible transcription factor in breast cancer and SUVmax of F-18 FDG PET/CT.

  title={Correlation of hypoxia inducible transcription factor in breast cancer and SUVmax of F-18 FDG PET/CT.},
  author={Young Ju Jeong and Jae-Won Jung and Yoon Young Cho and Sung-Hwan Park and Hoon Kyu Oh and Sungmin Kang},
  journal={Nuclear medicine review. Central \& Eastern Europe},
  volume={20 1},
BACKGROUND Tumor hypoxia induces the expression of several genes via the hypoxia-inducible transcription factor-1 alpha (HIF-1a). It is associated with the prognosis of several cancers. We studied the immunohistochemical expression of HIF-1a in patients with invasive ductal cancer (IDC) of the breast and the possible correlation with the maximum standardized uptake value of the primary tumor (pSUVmax) as well as other biological parameters. Prognostic significance of pSUVmax and expression of… 

Figures and Tables from this paper

Reverse Warburg Effect-Related Mitochondrial Activity and 18F-FDG Uptake in Invasive Ductal Carcinoma

There was a significant positive correlation between 18F-FDG uptake and the mitochondrial activity of cancer cells in patients with IDCB, and increased 18F’s uptake and mitochondrial activity were significantly associated with a shorter DFS.

Potential Utility of FDG PET-CT as a Non-invasive Tool for Monitoring Local Immune Responses

FDG uptake on PET-CT could be associated with TILs, especially regulatory T cells, in gastric cancer, and this finding may suggest that PET- CT could be of use as a non-invasive tool for monitoring the tumor microenvironment in patients with Gastric cancer.

Hypoxia Mediates Tumor Malignancy and Therapy Resistance.

This book chapter reviewed the causes and types of intratumoral hypoxia, Hypoxia detection methods, and the oncogenic role of HIF in tumorigenesis and chemo- and radio-therapy resistance.

Correlating imaging parameters with molecular data: An integrated approach to improve the management of breast cancer patients

The goal of this review is to provide an overview of the studies aimed at integrating imaging parameters with molecular biomarkers for improving breast cancer patient’s diagnosis and prognosis. The

Current insights and future perspectives of hypoxia-inducible factor-targeted therapy in cancer

  • T. Ajith
  • Biology
    Journal of basic and clinical physiology and pharmacology
  • 2018
A review article discusses the recent update on the HIF-targeted therapy in cancer and finds that HIFs remain one of the promising antiangiogenic agents as well as a direct target for interfering with the energetic of cancer cells in order to regulate the tumor growth.



Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis.

The level of HIF-1 alpha increases as the pathologic stage increases and is higher in poorly differentiated lesions than in the corresponding type of well-differentiated lesions.

Prognostic Value of Primary Tumor Uptake on F-18 FDG PET/CT in Patients with Invasive Ductal Breast Cancer

pSUVmax on pretreatment F-18 FDG PET/CT could be used as a good surrogate marker for the prediction of progression in patients with IDC and was significantly related to a higher stage of tumor size and grade.

Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer

Investigating the prognostic impact of different HIF-1α overexpression patterns in relation to its downstream effectors carbonic anhydrase (CA) IX and glucose transporter 1 (GLUT-1) found patients with diffuse Hif-1 α staining had a significantly better prognosis than patients with perinecrotically overexpressed HIF -1α.

¹⁸F-FDG uptake on PET could be a predictive marker of excision repair cross-complementation group 1 (ERCC1) expression in patients with thoracic neoplasms?

The results indicated that 18F-FDG uptake may be an alternative biomarker for predicting ERCC1 expression in patients with thymoma.

18F-FDG Uptake by Metastatic Axillary Lymph Nodes on Pretreatment PET/CT as a Prognostic Factor for Recurrence in Patients with Invasive Ductal Breast Cancer

Nodal SUVmax on pretreatment 18F-FDG PET/CT may be an independent prognostic factor for disease recurrence in patients with IDC and found to be a single determinant of DFS by multivariate analysis.

Correlation of Glut-1 glucose transporter expression with.

Findings suggest that Glut-1 expression is related to [18F]FDG uptake in non-small cell lung cancer, and correlated with the degree of cell differentiation in adenocarcinomas.

Prognostic importance of the standardized uptake value on (18)F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: An analysis of 125 cases. Leuven Lung Cancer Group.

It is concluded that the FDG uptake in primary NSCLC on PET has an important prognostic value and could be complementary to other well-known factors in the decision on adjuvant treatment protocols.

Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

The prognostic value of HIF‐1α expression and its correlation with various clinicopathologic variables in patients with invasive breast carcinoma were investigated.

Hypoxia-Induced increase in FDG uptake in MCF7 cells.

The hypoxia-induced increase in 3H-FDG uptake in MCF7 cells is the result, in part, of an increase in glucose transporter activity resulting from the modification (reduction) of thiol group(s) in the glucose transport protein(s).

18F-FMT Uptake Seen Within Primary Cancer on PET Helps Predict Outcome of Non–Small Cell Lung Cancer

Uptake of 18F-FMT in primary tumors was an independent prognostic factor in patients with pulmonary adenocarcinoma and was confirmed as a significant factor in predicting a poor prognosis.