Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study.

@article{Wright2003CorrelationOH,
  title={Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study.},
  author={Colin W. Wright and Miranda Gott and B. T. Grayson and Maya Hanna and Alison G Smith and Ahmet Tevfik Sunter and Joanna C. Neill},
  journal={Journal of psychopharmacology},
  year={2003},
  volume={17 4},
  pages={403-8}
}
Extracts of the herb St John's Wort have been shown to reduce alcohol intake in alcohol-preferring rats, but it is not known which of the constituent(s) are responsible for this effect. In this study, the effect of a crude methanolic extract of Hypericum perforatum (negligible hyperforin content) on alcohol drinking in C57BL/6J alcohol-preferring mice was compared with that of a hyperforin-rich extract (45% hyperforin) prepared by extracting the herb with supercritical carbon dioxide. The dose… CONTINUE READING

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