Correlation of genetic instability with mismatch repair protein expression and p53 mutations in non-small cell lung cancer.

@article{Chang2000CorrelationOG,
  title={Correlation of genetic instability with mismatch repair protein expression and p53 mutations in non-small cell lung cancer.},
  author={J W Chang and Yi Charlie Chen and C Y Chen and J T Chen and Sarah K Chen and Y C Wang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 5},
  pages={1639-46}
}
To examine the etiological association of genetic instability in lung tumorigenesis, we investigated the frequency of microsatellite instability (MI) of eight dinucleotide repeat markers in 68 patients with non-small cell lung cancer. Twenty-eight patients (41.2%) evidenced instability in multiple tested microsatellite markers ranging from 3-7 and were defined as MI-positive patients. MI occurred more frequently in patients suffering from squamous cell lung carcinoma (P = 0.004). We examined… CONTINUE READING
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High frequency of deletion mutations in p53 gene from squamous-cell lung cancer patients in Taiwan

  • Wang, Y-C, +7 authors H. Lee
  • Cancer Res.,
  • 1998
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