Correlation of functional domains and rates of nucleotide substitution in cytochrome b.

@article{Griffiths1997CorrelationOF,
  title={Correlation of functional domains and rates of nucleotide substitution in cytochrome b.},
  author={Carole S Griffiths},
  journal={Molecular phylogenetics and evolution},
  year={1997},
  volume={7 3},
  pages={352-65}
}
Distinguishing noise from signal presents a problem when DNA sequences are used for phylogeny reconstruction. Multiple substitutions at sites are a primary cause of noise and this is compounded by variation in substitution rates among sites. For protein-coding genes, one method used to determine if data are noisy is to assess levels of saturation of substitutions by codon position. However, this procedure may not be a fine enough filter for assessing noise. Variation in substitution rates may… CONTINUE READING

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