Correlation of dynamic contrast‐enhanced MRI derived volume transfer constant with histological angiogenic markers in high‐grade gliomas

  title={Correlation of dynamic contrast‐enhanced MRI derived volume transfer constant with histological angiogenic markers in high‐grade gliomas},
  author={Ningning Di and Chenjun Yao and Wenna Cheng and Yan Ren and Jianxun Qu and Bin Wang and Zhenwei Yao},
  journal={Journal of Medical Imaging and Radiation Oncology},
  • N. Di, C. Yao, +4 authors Zhenwei Yao
  • Published 1 August 2018
  • Medicine
  • Journal of Medical Imaging and Radiation Oncology
To ascertain if the volume transfer constant (Ktrans) derived from T1 dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) correlates with the immunohistological markers of angiogenesis in high‐grade gliomas. 
8 Citations
The Relationship Between Biological and Imaging Characteristics in Enhancing and Nonenhancing Glioma
This work focuses on physiologic and metabolic MR imaging techniques including diffusion, perfusion, and spectroscopy, as they relate to histopathology and molecular features of gliomas.
Can dynamic contrast-enhanced MRI evaluate VEGF expression in brain glioma? An MRI-guided stereotactic biopsy study.
DCE-MRI is a useful, non-invasive imaging technique for quantitative evaluation of V EGF, and its parameter Ktrans other than Kep, Ve or Vp may be used as a surrogate for VEGF expression in brain gliomas.
Association Between DCE-MRI Perfusion Histogram Parameters and EGFR and VEGF Expressions in Different Lauren Classifications of Advanced Gastric Cancer
  • Zhiheng Li, Zhenhua Zhao, +6 authors Zengxin Lu
  • Pathology & Oncology Research
  • 2021
Objective: To investigate the correlations between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion histogram parameters and vascular endothelial growth factor (VEGF) and
DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study
The DCE-MRI kinetic parameters show correlations with microvascular parameters in vital tissue and also reveal blood-brain barrier abnormalities in the infiltration zones adequate to differentiate glioma prognostic groups.
A radiomics model based on DCE-MRI and DWI may improve the prediction of estimating IDH1 mutation and angiogenesis in gliomas.
  • Jie Wang, Yue Hu, +4 authors Z. Jia
  • Medicine
    European journal of radiology
  • 2022
The radiomics model based on DCE-MRI and DWI can have a considerable effect on the evaluation of IDH1 mutation and angiogenesis in gliomas.
Non-Invasive Estimation of Glioma IDH1 Mutation and VEGF Expression by Histogram Analysis of Dynamic Contrast-Enhanced MRI
VEGF expression is significantly lower in IDH1mut gliomas as compared to the wildtype counterpart, and it is non-invasively predictable with histogram analysis of DCE-MRI.
Evaluation of the Prognosis of Neuroglioma Based on Dynamic Magnetic Resonance Enhancement.
The results showed that Cox proportional hazard model analysis showed that preoperative KPS score, age, tumor pathological grade, postoperative radiotherapy, temozolomide use, and Ki-67 expression had an impact on the prognosis of patients with neuroglioma.
Associations between Histogram Analysis Parameters Derived from DCE-MRI and Histopathological Features including Expression of EGFR, p16, VEGF, Hif1-alpha, and p53 in HNSCC
Background Our purpose was to elucidate possible correlations between histogram parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) with several histopathological features in head and


3D dynamic contrast‐enhanced MRI of rectal carcinoma at 3T: Correlation with microvascular density and vascular endothelial growth factor markers of tumor angiogenesis
To determine how dynamic contrast‐enhanced MRI at 3T correlates with rectal carcinoma angiogenesis, DCE MRI at3T is used as a surrogate for rectal cancer diagnosis.
Dynamic contrast‐enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis
The aim of this study was to investigate the use of magnetic resonance imaging (MRI) for non‐invasive measurement of rectal cancer angiogenesis and hypoxia.
Evaluation of Microvascular Permeability with Dynamic Contrast-Enhanced MRI for the Differentiation of Primary CNS Lymphoma and Glioblastoma: Radiologic-Pathologic Correlation
Findings confirm initial observations from perfusion CT and dynamic contrast-enhanced MR imaging studies, correlating with underlying histopathologic features, and may be useful in distinguishing primary central nervous system lymphoma from glioblastoma.
Preoperative Prognostic Value of Dynamic Contrast-Enhanced MRI–Derived Contrast Transfer Coefficient and Plasma Volume in Patients with Cerebral Gliomas
In patients with glioma, those with a high contrast transfer coefficient have lower survival than those with low parameters, and in multivariate analysis, a low Karnofsky score, biopsy versus resection in combination with marked contrast enhancement, and a high Contrast transfer coefficient were associated with lower survival rates.
Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome.
DCE-MRI may facilitate noninvasive preoperative predictions of areas of tumor with increased hypoxia and proliferation and has the potential to allow unprecedented prognostic decisions and to guide therapies to specific tumor areas.
In Vivo Correlation of Tumor Blood Volume and Permeability with Histologic and Molecular Angiogenic Markers in Gliomas
In vivo evaluation of in vivo correlation of PCT parameters such as CBV and PS with histologic and molecular angiogenic markers in gliomas suggests that these 2 perfusion parameters represent different aspects of tumor vessels; hence, in vivo evaluated of these could be important in a better understanding of tumor angiogenesis.
Estimating kinetic parameters from dynamic contrast‐enhanced t1‐weighted MRI of a diffusable tracer: Standardized quantities and symbols
We describe a standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast‐enhanced T1‐weighted magnetic resonance imaging data, using diffusable
Perfusion Parameters of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Patients with Rectal Cancer: Correlation with Microvascular Density and Vascular Endothelial Growth Factor Expression
DCE-MRI perfusion parameters, Ktrans and Ve, correlated poorly with MVD and VEGF expression scores in rectal cancer, suggesting that these parameters do not simply denote static histological vascular properties.
Glioblastoma treated with concurrent radiation therapy and temozolomide chemotherapy: differentiation of true progression from pseudoprogression with quantitative dynamic contrast-enhanced MR imaging.
Dynamic contrast-enhanced MR imaging-derived pharmacokinetic parameters, including K(trans) and ve, in the entire newly developed or enlarged enhancing lesion may be useful objective diagnostic tools in the differentiation of true progression from pseudoprogression in patients with glioblastoma who have undergone concurrent radiation therapy and chemotherapy with temozolomide.
VEGF Expression in Osteosarcoma Correlates with Vascular Permeability by Dynamic MRI
The preliminary results in this study show an association between vascular endothelial growth factor and dynamic MR signal enhancement in osteosarcoma, which should be investigated as a means to prognosticate patients with osteosARcoma according to their tumor angiogenic activity.