Correlation of drug absorption with molecular surface properties.

@article{Palm1996CorrelationOD,
  title={Correlation of drug absorption with molecular surface properties.},
  author={Katrin Palm and Kristina Luthman and A L Ungell and Gert Strandlund and Per Artursson},
  journal={Journal of pharmaceutical sciences},
  year={1996},
  volume={85 1},
  pages={32-9}
}
The correlation between dynamic surface properties of drug molecules and drug absorption in two common in vitro models of the intestinal wall (Caco-2 monolayers and rat intestinal segments) has been investigated. A homologous series of beta-adrenoreceptor antagonists were used as model compounds. Dynamic molecular surface properties, considering all low-energy conformations, of the compounds were calculated. The flexibility of the molecules was studied by molecular mechanics calculations (MM2… CONTINUE READING

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