Correlation of diafiltration sieving behavior of lysozyme-BSA mixtures with osmotic second virial cross-coefficients.

@article{Tessier2004CorrelationOD,
  title={Correlation of diafiltration sieving behavior of lysozyme-BSA mixtures with osmotic second virial cross-coefficients.},
  author={Peter M Tessier and Vincent J. Verruto and Stanley I. Sandler and Abraham M Lenhoff},
  journal={Biotechnology and bioengineering},
  year={2004},
  volume={87 3},
  pages={
          303-10
        }
}
The role of protein-protein interactions in membrane separations of protein mixtures remains incompletely understood, largely due to the difficulty of characterizing protein self- and, especially, cross-association. Recently, a novel technique, cross-interaction chromatography, has been developed to measure weak protein cross-association in terms of the osmotic second virial cross-coefficient. In this work the relationship between protein cross-association and the sieving behavior of lysozyme… CONTINUE READING
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