Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.

@article{Tarin1982CorrelationOC,
  title={Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours.},
  author={David Tarin and B. J. Hoyt and David W Evans},
  journal={British Journal of Cancer},
  year={1982},
  volume={46},
  pages={266 - 278}
}
We report evidence for the secretion of a true mammalian collagenase active against Type 1 collagen, by naturally-occurring mammary tumours of the mouse and show that tumours capable of heavily colonizing the lungs secrete significantly more of this enzyme than those with low pulmonary-colonization potential, or non-neoplastic proliferating (e.g. lactating) mammary tissue. Plasminogen activator is secreted in greater quantity by tumours than by normal tissues, but there is no significant… CONTINUE READING

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Experimental analysis of factors affecting metastatic spread using naturallyoccurring tumours

  • D. TARIN
  • Invasion and Metastasies
  • 1982

Collagen - ase immunolocalization studies of cutaneous secondary melanomas

  • M. K. DABBOUS, K. HASHIMOTO
  • Br . J . Cancer
  • 1980

Collagenase , lysosomes and osteo - clastic bone resorption

  • B. S. WANG, G. A. MCLOUGHLIN, J. P. RICHIE, J. A. MANNICK
  • Collagenase in Normal and Pathological Connective…
  • 1980

Collagenase immunolocalization studies of rheumatoid

  • J. M. EVANSON
  • 1980

Collagenase immunolocalization studies of rheumatoid and malignant tissues

  • D. E. WOOLLEY, C. A. GRAFTON
  • Collagena 8 e in Normal and Pathological…
  • 1980
1 Excerpt

Collagenase in uterine resorption

  • J. F. WOESSNER, JR
  • Collagena 8 e in Normal and Pathological…
  • 1980

Content and characterization of plasminogen activators in human lung tumors and normal lung tissue

  • B. NAGY, J. BAN, B. BRDAR
  • Cancer Res .
  • 1980

Correlation of the production of plasminogen activator with tumor metastasis in B 16 mouse melanoma cell lines

  • G. WIRL, J. FRICK
  • Cancer Re
  • 1980

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