Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging.

@article{Allard2012CorrelationOC,
  title={Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging.},
  author={Simon Allard and Tina Scardochio and Augusto Claudio Cuello and Alfredo Ribeiro-da-Silva},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 7},
  pages={1466-80}
}
It is well established that the cerebral cortex undergoes extensive remodeling in aging. In this study, we used behaviorally characterized rats to correlate age-related morphological changes with cognitive impairment. For this, young and aged animals were tested in the Morris water maze to evaluate their cognitive performance. Following behavioral characterization, the animals were perfused and a combination of intracellular labeling and immunohistochemistry was applied. Using this approach, we… CONTINUE READING

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