Correlation of clinical response with homocysteine reduction during therapy with reduced B vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism: a randomized, double-blind, placebo-controlled study.

@article{Mech2016CorrelationOC,
  title={Correlation of clinical response with homocysteine reduction during therapy with reduced B vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism: a randomized, double-blind, placebo-controlled study.},
  author={Arnold W Mech and Andrew Farah},
  journal={The Journal of clinical psychiatry},
  year={2016},
  volume={77 5},
  pages={
          668-71
        }
}
  • A. MechA. Farah
  • Published 25 May 2016
  • Medicine, Psychology, Biology
  • The Journal of clinical psychiatry
OBJECTIVE This study was designed to evaluate the efficacy and safety of reduced B vitamins as monotherapy in adults with major depressive disorder (MDD) who were also positive for at least 1 methylenetetrahydrofolate reductase (MTHFR) polymorphism associated with depression and further test the hypothesis that reduced (metabolized) B vitamins will lower homocysteine in a majority of clinically responding patients. METHODS 330 adult patients with MDD (DSM-5) and positive for either MTHFR… 

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