Correlation of clinical, endocrine and molecular abnormalities with in vivo responses to high-dose testosterone in patients with partial androgen insensitivity syndrome.

@article{Tincello1997CorrelationOC,
  title={Correlation of clinical, endocrine and molecular abnormalities with in vivo responses to high-dose testosterone in patients with partial androgen insensitivity syndrome.},
  author={Douglas G Tincello and P T K Saunders and Malcolm B Hodgins and Nick Simpson and Christopher R. W. Edwards and T B Hargreaves and Fredrick C W Wu},
  journal={Clinical endocrinology},
  year={1997},
  volume={46 4},
  pages={497-506}
}
OBJECTIVE To investigate the responses of two patients previously diagnosed as Reifenstein's syndrome to graded high-dose testosterone in terms of hormone levels, nitrogen balance and sebum secretion and to attempt to correlate these parameters with the properties of their androgen receptors and mutations in the androgen receptor gene. DESIGN Nitrogen balance was determined by comparing controlled nitrogen intake to the amount excreted. Sebum excretion was measured on the forehead. Patients… CONTINUE READING

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