Correlation of changes in the GABA-ergic system with the development of spasticity in paraplegic cats.

@article{Naftchi1979CorrelationOC,
  title={Correlation of changes in the GABA-ergic system with the development of spasticity in paraplegic cats.},
  author={N. Naftchi and W. Schlosser and W. D. Horst},
  journal={Advances in experimental medicine and biology},
  year={1979},
  volume={123},
  pages={
          431-50
        }
}
Following spinal cord transection there occurred decreases in Km and Vmax of glutamate decarboxylase (GAD) both above and below the lesion, and an initial decrease in the concentration of GABA. Concomitantly, there was a gradual decrease in presynaptic inhibition. Eight to 12 weeks after spinal cord transection, Km and Vmax for GAD returned to control values, but the GABA content of the spinal cord below the lesion increased significantly and presynaptic inhibition became maximally depressed… Expand
GABA receptor agonists: Pharmacological spectrum and therapeutic actions
Antispasticity drugs: Mechanisms of action
  • Robert A. Davidoff
  • Chemistry, Medicine
  • Annals of neurology
  • 1985
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