Correlation of c-erbB-2 oncogene and p53 tumor suppressor gene with malignant transformation of hydatidiform mole.

@article{YazakiSun2006CorrelationOC,
  title={Correlation of c-erbB-2 oncogene and p53 tumor suppressor gene with malignant transformation of hydatidiform mole.},
  author={Sue Yazaki-Sun and Silvia Daher and M{\'a}rcia Marcelino de Souza Ishigai and Maria Teresa de Seixas Alves and Teresa Meire Mantovani and Rosiane Mattar},
  journal={The journal of obstetrics and gynaecology research},
  year={2006},
  volume={32 3},
  pages={265-72}
}
AIM Considering the roles of c-erB-2 and p53 oncoproteins in tumor progression, we aimed to evaluate their expression in hydatidiform moles, and the possible predictive value of this immunoexpression in postmolar follow-up. METHODS Group I comprised 35 patients with progression to gestational trophoblastic tumor, and group II included 32 patients with progression to spontaneous remission. Immunohistochemical tests were performed by streptavidin-peroxidase method. c-erbB-2 immunoexpression was… CONTINUE READING

Similar Papers

Loading similar papers…