Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity.

@article{Lehrer1985CorrelationOB,
  title={Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity.},
  author={Robert I. Lehrer and Dorothy Szklarek and Tomas Ganz and Michael E Selsted},
  journal={Infection and immunity},
  year={1985},
  volume={49 1},
  pages={207-11}
}
NP-1, a candidacidal peptide purified from rabbit granulocytes, bound extensively and with biphasic kinetics to Candida albicans. The primary phase of binding was temperature independent and occurred even at 0 degrees C. This primary binding was relatively specific, reversible, saturable, and of high capacity. It was inhibited by increased salt concentrations in the incubation medium, but was relatively unaffected by increasing the calcium ion concentration or by lowering the incubation… CONTINUE READING

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