Correlation of abnormal mitochondrial distribution in mouse oocytes with reduced developmental competence.

@article{Nagai2006CorrelationOA,
  title={Correlation of abnormal mitochondrial distribution in mouse oocytes with reduced developmental competence.},
  author={Seiichiro Nagai and Tadashi Mabuchi and Shuji Hirata and Tomoko Shoda and Tsuyoshi Kasai and Sadaki Yokota and Hiroshi Shitara and Hiromichi Yonekawa and Kazuhiko Hoshi},
  journal={The Tohoku journal of experimental medicine},
  year={2006},
  volume={210 2},
  pages={137-44}
}
Selection of good quality oocytes is important for improvement of assisted reproductive technology. Here, we studied the relationship of the mitochondrial distribution in metaphase II stage (MII) oocytes with fertility, since mitochondria in ooplasm are essential for energy production required for fertilization and embryo development. To observe mitochondria non-invasively, we used oocytes from a transgenic mouse, in which enhanced green fluorescent protein is targeted to the mitochondrial… CONTINUE READING
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