Correlation of S Hemoglobin with Glucose-6-phosphate Dehydrogenase Deficiency and Its Significance.

Abstract

F ROM A RELATIVELY small series of cases, Lewis and Hathor& coneluded that there is a correlation between the incidence of glucose-6-phosphate dehydrogenase deficiency ( G-6-PD) and S hemoglobin. It was suggested that G-6-PD defect protects against the hazards of sickle cell disease, and that this might account for the high incidence of the enzyme deficiency in mdividuals with an abnormal hemoglobin pattern. Now that more cases have been studied, the original findings have been confirmed, and it is possible to compare the incidence of the defect in sickle cell-hemoglobin C disease, sickle cell anemia and sickle cell thalassemia. Meanwhile, Allison2 has drawn our attention to conflicting observations made by Naybor et al.3 Their data are compared with ours and the conflicting conclusions are explained by differences in methodology and interpretation.

Cite this paper

@article{LEWIS1965CorrelationOS, title={Correlation of S Hemoglobin with Glucose-6-phosphate Dehydrogenase Deficiency and Its Significance.}, author={R A LEWIS and Marty Hathorn}, journal={Blood}, year={1965}, volume={26}, pages={176-80} }