Correlation of Pneumococcal Antibody Concentration and Avidity with Patient Clinical and Immunologic Characteristics

@article{Fried2013CorrelationOP,
  title={Correlation of Pneumococcal Antibody Concentration and Avidity with Patient Clinical and Immunologic Characteristics},
  author={Ari J. Fried and Michelle L. Altrich and Hongye Liu and John F. Halsey and Francisco A. B. Bonilla},
  journal={Journal of Clinical Immunology},
  year={2013},
  volume={33},
  pages={847-856}
}
The quality of an antibody response is determined by both the concentration and the strength of antigen-binding, or avidity, of the antibodies produced. Currently, only antibody concentration is routinely evaluated in the clinical assessment of humoral immunity. Here we studied correlations of avidities and concentrations of antibodies to pneumococcal polysaccharides with immunologic and clinical characteristics of patients with recurrent infections. We measured concentration and avidity of… CONTINUE READING