Correlation of O4-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine.

Abstract

Recent experiments have demonstrated that O6-ethyldeoxyguanosine (O6-EtdG) is efficiently repaired while O4-ethyldeoxythymidine (O4-EtdT) accumulates in hepatocyte DNA of 8-week-old F-344 rats during continuous diethylnitrosamine (DEN) administration. To determine if O4-EtdT accumulation correlates with hepatic initiation, we have quantitated O4-EtdT… (More)

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